fig3

Figure 3. The neutral granulocytes loaded with metformin are coated with PBNZ (Met@PBN@Neu-CVs), which effectively alleviate hepatic ischemia-reperfusion injury (HIRI). (A) Schematic diagram of the synthesis and administration of Met@PBN@Neu-CVs for HIRI treatment; (B) Therapeutic effect of Met@PBN@Neu-CVs on liver IRI in rats. This figure is quoted with permission from Shen et al.^[66]. Here, * vs. Sham; # vs. IRI; & vs. IRI + Met; % vs. IRI + PBN@Neu-CVs, P < 0.05, N = 5.