fig4

Figure 4. MPM TME: from “cold” to “hot”. MPM: Malignant pleural mesothelioma; TME: tumor microenvironment; ICI: immune checkpoint inhibitor; CDKN2A: cyclin-dependent kinase inhibitor 2A; NF2: neurofibromin 2; TGF-β: transforming growth factor beta; Tregs: regulatory T cells; M2-TAM: M2-type tumor-associated macrophage; CD8⁺ T cells: cytotoxic T lymphocytes; MDSCs: myeloid-derived suppressor cells; PD-1: programmed cell death protein 1; IFN-γ: interferon γ; CXCL9/10: chemokine (C-X-C motif) ligand 9/10; BAP1: BRCA1-associated protein 1; ADI-PEG20: PEGylated arginine deiminase.