fig2
Figure 2. Schematic diagram of the oncogenic role of EV-transmitted LUCAT1 in bladder cancer. EV-transmitted LUCAT1 promotes the stemness phenotype and chemoresistance of BC cells via upregulating HMGA1 expression via binding to IGF2BP2, thus contributing to its oncogenic activity in bladder cancer pathogenesis[28]. EVs: Extracellular vesicles; BC: bladder cancer; GEM: gemcitabine; LUCAT1: lung cancer-associated transcript 1; HMGA1: high mobility group AT-hook 1; IGF2BP2: insulin-like growth factor 2 mRNA-binding protein 2; mRNA: messenger RNA.
