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Figure 5. Nanoplastic-mediated modulation of mechanotransduction and YAP signaling in HSCs. (A) Immunofluorescence staining of F-actin and YAP in HSCs treated with 10 μg/mL of positively or negatively charged nanoplastics; (B) Quantitative analysis of F-actin fluorescence intensity and YAP nuclear-to-cytoplasmic ratio; (C) Schematic illustration depicting the HSC cytoskeletal reorganization and mechanotransduction modulation induced by nanoplastics. YAP: Yes-associated protein; HSCs: hepatic stellate cells; PS-NH2: amino-functionalized polystyrene; PS-COOH: carboxyl-functionalized polystyrene; ECM: extracellular matrix.
