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From: Stimuli-responsive hydrogels for ocular tumor therapy

Figure 1. Schematic representation of stimuli-responsive hydrogels for ocular tumor therapy. (A) Classification of stimuli-responsive hydrogels according to internal (enzyme, pH, or redox) and external (temperature, light, ultrasound, or magnetic field) stimuli; (B) Therapeutic applications of stimuli-responsive hydrogels in ocular tumors, including chemotherapy, surgery, immunotherapy, and combinational therapy. TME, tumor microenvironment; PTT, photothermal therapy; CAR-T, chimeric antigen receptor T-cell immunotherapy. Created in BioRender. Li, H. (2026) https://BioRender.com/2ktdiv3. TME: Tumor microenvironment; PTT: photothermal therapy; CAR-T: chimeric antigen receptor T-cell; CTLA-4: cytotoxic T-lymphocyte-associated protein 4; PD-L1: programmed death ligand 1; CD8⁺: Cluster of Differentiation 8-positive.