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From: Stimuli-responsive hydrogels for ocular tumor therapy

Figure 4. Stimuli-responsive hydrogels for postsurgical and local immunotherapy of ocular tumors. (A) Schematic illustration of an immunotherapeutic AVB hydrogel constructed from highly branched polymers for postsurgical management of choroidal melanoma, enabling localized tumor control and preservation of visual function; (B) Synthetic route of AVB hydrogel by a two-step process; (C) Representative photographs (upper panel) and corresponding hematoxylin and eosin (H&E)-stained histopathological sections (lower panel) of mouse eyes from each experimental group. Scale bar 1 mm. Figure 4A-C is quoted with permission from Chen et al.^[155]. AVB: Artificial vitreous body; Mel: melphalan; MA: maleimide groups; SH: sulfhydryl groups; αPDL1: anti-programmed death ligand 1; IFN-g: interferon-g; TNF-α: tumor necrosis factor-α; DAMP: damage-associated molecular pattern; CTL: cytotoxic T lymphocyte; DC: dendritic cell; PEG: poly(ethylene glycol).