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Figure 3. Bilirubin administration ameliorates glucose tolerance and enhances insulin sensitivity in HFD-fed mice. (A and B) Bilirubin administration significantly decreased blood insulin levels (A) and blood glucose levels (B) in HFD-fed mice; (C) Effects of bilirubin on glucose homeostasis in high-fat diet-induced obese mice, as assessed by OGTT; (D) Effects of bilirubin on insulin resistance in HFD-fed mice, as determined by ITT; (E) Quantitative analysis of the AUC for OGTT in (C); (F) Quantitative analysis of the AUC for ITT in (D). HFD: High-fat diet; OGTT: oral glucose tolerance test; ITT: insulin tolerance test; AUC: area under the curve. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001 vs. HFD.