fig6

Figure 6. Design of dual-programmable semiconducting polymer nanoPROTACs (SPN_FeP) for activatable combination immunotherapy of deep-tissue tumors. (A) Scheme for preparation of SPN_FeP via nano-precipitation and dual- programmable activation mechanism; (B) Scheme for dual-programmable activation of SPN_FeP, mechanism of SDT and ferroptosis, immune response activation, and suppression of MDSC expansion for immunotherapy of deep-tissue tumors. Reproduced with permission^[123]. Copyright 2024, Small. US: Ultrasound; PROTAC: proteolysis targeting chimera; DSPE-TK-PEG: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-Thioketal-Polyethylene Glycol; PFODBT: poly[2,7-(9,9-di-octyl-fluorene)-alt-4,7-bis(thiophen-2-yl)benzo-2,1,3-thiadiazole]; GPX-4: glutathione Peroxidase 4; GSH: glutathione (Reduced Glutathione); HMGB1: high-mobility group box protein 1; CRT: calreticulin; MDSC: myeloid-derived suppressor cell; CD4⁺: CD8⁺: cluster of differentiation 8 (positive); SDT: sonodynamic therapy; ROS: reactive oxygen species; NAMPT: nicotinamide phosphoribosyltransferase; NAD⁺: nicotinamide adenine dinucleotide; ICD: immunogenic cell death.